%0 Journal Article
%T SPECTROPHOTOMETRIC METHOD FOR RANITIDINE DETERMINATION IN DRUGS USING RHODAMINE B
%A ZENOVIA MOLDOVAN
%A HASSAN Y ABOUL-ENEIN
%J Journal of the Chilean Chemical Society
%D 2012
%I Sociedad Chilena de Qu¨ªmica
%X A new spectrophotometric method has been developed for the determination of ranitidine hydrochloride (RHCl) in bulk drug and in tablet formulation. The proposed method involves the addition of a measured excess of bromate-bromide reagent in hydrochloric acid medium to RHCl, followed by determination of residual bromine by reacting with a fixed amount of Rhodamine B (RB) and measuring the absorbance at ¦Ëmax=557 nm. Beer's law was found in the range of 0.3-3.2 ¦Ìg ml-1 of RHCl, with a good correlation coefficient (r=0.9997). The limits of detection and quantification were calculated to be 0.08 ¦Ìg ml-1 and 0.24 ¦Ìmg ml-1, respectively. The different experimental parameters affecting the development and stability of the proposed method were carefully studied and optimized. The validity of the proposed method tested by analyzing the pure and pharmaceutical formulations and compared well with those obtained by the official method, demonstrated good accuracy and precision.
%K Spectrophotometry
%K Ranitidine hydrochloride
%K Rhodamine B
%K Redox reaction
%K Drug
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400018