%0 Journal Article
%T SYNTHESIS AND AChE INHIBITING ACTIVITY OF 2, 4 SUBSTITUTED 6-PHENYL PYRIMIDINES
%A CRISTIAN PAZ
%A MARTIN G PETER
%A BERND SCHMIDT
%A JOSE BECERRA
%J Journal of the Chilean Chemical Society
%D 2012
%I Sociedad Chilena de Qu¨ªmica
%X Novel substituted pyrimidines were synthesized from methyl 2,4-dioxo-4-phenyl-butanoate (I-A) and urea, followed by Mitsunobu coupling of I-A with benzyl or allyl alcohol to give the corresponding 2-hydroxypyrimidine ethers in good yields. Saponification of I-A, followed by reaction with benzyl or allyl amines in the presence of TBTU yielded 2-hydroxy-6-phenyl-pyrimidine 4-carboxamides. AChE and BuChE assays revealed 2-hydroxy-6-phenyl-pyrimidine-4-carboxyallyamide as the most active compound, IC50= 90 ¦̀M, with no inhibition of BuChE.
%K Pyrimidines
%K inhibition AChE
%K mitsunobu
%K TBTU
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300020