%0 Journal Article
%T Effects of Aerobic Fitness and Adiposity on Coagulation Biomarkers in Men vs. Women with Elevated Blood Pressure
%A Kathleen L. Wilson
%A Lianne Tomfohr
%A Kate Edwards
%A Cindy Knott
%J European Journal of Cardiovascular Medicine
%D 2012
%I Healthcare Bulletin
%X ABSTRACTA hypercoagulable state is a potential mechanism linking elevated blood pressure (BP), adiposity and a sedentary lifestyle to development of coronary heart disease (CHD). We examined relationships among aerobic fitness and adiposity in 76 sedentary subjects with elevated BP. Blood levels of plasminogen activator inhibitor-1 (PAI-1), D-dimer, von Willebrand factor (vWF) and thrombomodulin were assessed as biomarkers of coagulation. In individuals with elevated BP, percent body fat and fitness were associated with biomarkers indicative of a hypercoagulable state, even after demographic and metabolic factors were considered. D-dimer was positively associated with percent body fat (beta=0.37, p=0.003). PAI-1 was higher in men than in women (beta=-0.31, p=0.015) and associated with lower VO2peak (beta=-0.35, p=0.024). Thrombomodulin was positively associated with VO2peak (beta=0.56, p< 0.01). vWF was not significantly associated with fitness or adiposity. Our results emphasise that both percent body fat and physical fitness are important in the maintenance of haemostatic balance.
%K fitness
%K adiposity
%K coagulation
%K hypertension
%K blood pressure
%K D-dimer. PAI-1
%K von Willebrand factor
%K thrombomodulin
%U ttp://www.healthcare-bulletin.com/journals/cardiovascular-medicine/the-european-journal-of-cardiovascular-medicine/details/article/effects-of-aerobic-fitness-and-adiposity-on-coagulation-biomarkers-in-men-vs-women-with-elevated-bl/