%0 Journal Article
%T Knoevenagel condensation of isatins with malononitrile/ethyl cyanoacetate in the presence of sulfonic acid functionalized silica (SBA-Pr-SO3H) as a new nano-reactor
%A Negar Lashgari
%A Ghodsi Mohammadi Ziarani
%A Alireza Badiei
%A Parisa Gholamzadeh
%J European Journal of Chemistry
%D 2012
%I 
%R 10.5155/eurjchem.3.3.310-313.659
%X The Knoevenagel condensation between isatins and active methylene compounds like malononitrile and ethyl cyanoacetate to prepare 2-oxoindolin-3-ylidene malononitrile/ cyanoacetates is described. The reactions occur in the presence of sulfonic acid functionalized silica SBA-15 (SBA-Pr-SO3H) in an aqueous medium giving excellent yields of the products in short reaction times. SBA-Pr-SO3H with a pore size of 6 nm is found to be an efficient and environmentally benign catalyst for this reaction.
%K Isatin
%K SBA-Pr-SO3H
%K Nano-reactor
%K Malononitrile
%K Knoevenagel condensation
%K 2-Oxoindolin-3-ylidene malononitrile
%U http://www.eurjchem.com/index.php/eurjchem/article/view/659