%0 Journal Article %T Nicotine and periodontal tissues %A Malhotra Ranjan %A Kapoor Anoop %A Grover Vishakha %A Kaushal Sumit %J Journal of the Indian Society of Periodontology %D 2010 %I Medknow Publications %X Tobacco use has been recognized to be a significant risk factor for the development and progression of periodontal disease. Its use is associated with increased pocket depths, loss of periodontal attachment, alveolar bone and a higher rate of tooth loss. Nicotine, a major component and most pharmacologically active agent in tobacco is likely to be a significant contributing factor for the exacerbation of periodontal diseases. Available literature suggests that nicotine affects gingival blood flow, cytokine production, neutrophil and other immune cell function; connective tissue turnover, which can be the possible mechanisms responsible for overall effects of tobacco on periodontal tissues. Inclusion of tobacco cessation as a part of periodontal therapy encourages dental professionals to become more active in tobacco cessation counseling. This will have far reaching positive effects on our patientsˇä oral and general health. %K Nicotine %K smoking %K smoking cessation %K tobacco %U http://www.jisponline.com/article.asp?issn=0972-124X;year=2010;volume=14;issue=1;spage=72;epage=79;aulast=Malhotra