%0 Journal Article
%T Estrategias para disminuir los eventos adversos m芍s frecuentes relacionados con bloqueadores neuromusculares Strategies to Reduce the Most Frequent Adverse Events of Neuromuscular Blocking Agents
%A Fredy Ariza Cadena
%J Revista Colombiana de Anestesiolog赤a
%D 2012
%I Sociedad Colombiana de Anestesiolog赤a
%R 10.1016/s0120-3347(12)70026-6
%X Los bloqueadores neuromusculares (BNM) son, sin duda, los medicamentos m芍s asociados a los eventos adversos perioperatorios con que debe lidiar el anestesi車logo. Reconocer y tratar a los pacientes con alto riesgo de eventos inesperados relacionados con la aplicaci車n de estos medicamentos debe convertirse en una rutina para el especialista en medicina perioperatoria. Este art赤culo de reflexi車n plantea sencillos conceptos de farmacocin谷tica y farmacodin芍mica que permiten al anestesi車logo hacer m芍s segura la administraci車n de BNM. La preservaci車n de la homeostasis interna, la termoprotecci車n y asegurar la microcirculaci車n son estrategias b芍sicas para disminuir eventos como la curarizaci車n residual postoperatoria. Por otra parte, un adecuado enfoque cl赤nico para pacientes en riesgo de reacciones de hipersensibilidad a BNM permite brindarles un manejo seguro e integral, previniendo posteriores eventos de mayor severidad o incluso fatales. Neuromuscular blocking agents are without doubt the drugs most frequently associated with perioperative adverse events in anesthesia. Acknowledging and treating those patients at high risk of developing unexpected events caused by the administration of these agents should become a routine for the perioperative medicine specialist. This article is a reflection on simple pharmacokinetics and pharmacodynamics for improved safety in the administration of NMBs by the anesthesiologist. Preserving internal homeostasis, thermoprotection and securing microcirculation are key strategies for reducing events such as postoperative residual curarization. Furthermore, a right clinical approach to patients at high risk of developing NMBrelated hypersensitivity reactions enables a safe and comprehensive management of the patient, avoiding subsequent and more severe or even fatal events.
%K Bloqueadores neuromusculares
%K farmacocin谷tica
%K bloqueo neuromuscular
%K procedimientos quir迆rgicos
%K ambulatorios
%K Neuromuscular blocking agents
%K Pharmacokinetics
%K Neuromuscular blockade
%K Ambulatory surgical procedures
%U http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-33472012000200009