%0 Journal Article
%T Developing a yeast cell factory for the production of terpenoids
%A Sotirios C Kampranis
%A Antonios Michael Makris
%J Computational and Structural Biotechnology Journal
%D 2012
%I Research Network of Computational and Structural Biotechnology
%X Technological developments over the past century have made microbes the work-horses of large scale industrial production processes. Current efforts focus on the metabolic engineering of microbial strains to produce high levels of desirable end-products. The arsenal of the contemporary metabolic engineer contains tools that allow either targeted rational interventions or global screens that combine classical approaches with ¨Comics technologies. Production of terpenoids in S. cerevisiae presents a characteristic example of contemporary biotechnology that integrates all the variety of novel approaches used in metabolic engineering. Terpenoids have attracted significant interest as pharmaceuticals, flavour and fragrance additives, and, more recently, biofuels. The ongoing metabolic engineering efforts, combined with the continuously increasing number of terpene biosynthetic enzymes discovered will enable the economical and environmentally friendly production of a wide range of compounds.
%U http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201210006