%0 Journal Article
%T Colestasis postinfecci¨®n por virus de Epstein-Barr sin elevaci¨®n de gamma glutamil transpeptidasa Post-infection cholestasis due to Epstein-Barr virus infection without elevation of gamma glutamyl transpeptidase
%A B. Gorozarri Gallo
%A A. Grande Benito
%A R. Torres Peral
%A L. Ramos D¨ªaz
%J Bolet¨ªn de Pediatr¨ªa
%D 2010
%I Sociedad de Pediatr¨ªa de Asturias, Cantabria y Castilla y Le¨®n
%X El virus de Epstein-Barr es el agente responsable de la mayor¨ªa de los casos de mononucleosis infecciosa, s¨ªndrome linfoproliferativo que suele ser benigno y autolimitado, aunque puede acompa arse en ocasiones de complicaciones neurol¨®gicas, respiratorias o hematol¨®gicas. A la sintomatolog¨ªa cl¨ªnica habitual, caracterizada por fiebre, malestar general, odinofagia y adenopat¨ªas generalizadas, es frecuente que se asocie una hepatopat¨ªa subcl¨ªnica, caracterizada en el ni o por un leve y transitorio aumento de las transaminasas. A diferencia del adulto, en el ni o, la existencia de un s¨ªndrome colest¨¢sico es excepcional. Presentamos el caso cl¨ªnico de una ni a de 6 a os que presenta una colestasis cl¨ªnico-bioqu¨ªmica en el curso de una infecci¨®n aguda por el virus de Epstein-Barr, en la que destaca la normalidad de las cifras de gamma glutamil transpeptidasa durante toda la evoluci¨®n de su proceso. The Epstein-Barr virus is the responsible agent for most of the cases of infectious mononucleosis, a lymphoproliferative syndrome that is generally benign and self-limited, although it may sometimes be accompanied by neurological, respiratory or hematological complications. Frequently, it is frequent to find that subclinical liver disease, characterized in the child by mild and transitory increase of transaminases is associated to the usual clinical symptoms, characterized by fever, general malaise, odinophagia and generalized abnormal lymph nodes. On the contrary to the adult, the existence of a cholestatic syndrome in the child is rare. We present the case of a 6-year old girl who presented a clinical-biochemical cholestasis during an acute infection due to Epstein-Barr virus in which the normality of the gamma glutamyl transpeptidase values during the entire course stands outs.
%K Colestasis
%K virus Epstein-Barr
%K Cholestasis
%K Virus Epstein Barr
%U http://sccalp.org/documents/0000/1520/BolPediatr2010_50_017-020.pdf