%0 Journal Article
%T A review of analytical methods for the determination of four new phosphodiesterase type 5 inhibitors in biological samples and pharmaceutical preparations
%A Cristiane Franco Codevilla
%A Tamara dos Santos Castilhos
%A Ana Maria Bergold
%J Brazilian Journal of Pharmaceutical Sciences
%D 2013
%I Universidade de S?o Paulo
%X The introduction of oral phosphodiesterase type 5 inhibitor therapy in 1998 revolutionized the treatment of erectile dysfunction. Erectile dysfunction is the most common sexual problem in men. It often has a profound effect on intimate relationships and quality of life. The analysis of pharmaceuticals is an important part of the drug development process as well as for routine analysis and quality control of commercial formulations. Whereas the determination of sildenafil citrate, vardenafil and tadalafil are well documented by a variety of methods, there are few publications about the determination of udenafil, lodenafil carbonate, mirodenafil and avanafil. The paper presents a brief review of the action mechanism, adverse effects, pharmacokinetics and the most recent analytical methods that can determine drug concentration in biological matrices and pharmaceutical formulations of these four drugs. A introdu  o da terapia oral com inibidores da fosfodiesterase tipo 5, em 1998, revolucionou o tratamento da disfun  o er¨¦til. A disfun  o er¨¦til ¨¦ o problema sexual mais comum em homens. Muitas vezes tem um efeito profundo nas rela  es ¨ªntimas e na qualidade de vida. A an¨¢lise de produtos farmac¨ºuticos ¨¦ uma parte importante do processo de desenvolvimento de f¨¢rmacos, bem como para a an¨¢lise de rotina e controle de qualidade das formula  es comerciais. Enquanto a determina  o do citrato de sildenafila, vardenafila e tadalafila est¨¢ bem documentada por uma variedade de m¨¦todos, existem poucas publica  es sobre a determina  o de udenafila, carbonato de lodenafila, mirodenafila e avanafila. O artigo apresenta uma breve revis o do mecanismo de a  o, efeitos adversos, farmacocin¨¦tica e os mais recentes m¨¦todos anal¨ªticos, que podem determinar a concentra  o do f¨¢rmaco em matrizes biol¨®gicas e formula  es farmac¨ºuticas destes quatro f¨¢rmacos.
%K Inibidores da fosfodiesterase tipo 5
%K Inibidores da fosfodiesterase tipo 5
%K Inibidores da fosfodiesterase tipo 5
%K Inibidores da fosfodiesterase tipo 5
%K M¨¦todos anal¨ªticos
%K Disfun  o er¨¦til
%K Phosphodiesterase type 5 inhibitors
%K Phosphodiesterase type 5 inhibitors
%K Phosphodiesterase type 5 inhibitors
%K Phosphodiesterase type 5 inhibitors
%K Analytical methods
%K Erectile dysfunction
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100002