%0 Journal Article
%T Hematopoietic stem cell transplantation for thalassemia
%A Surapol Issaragrisil
%J Cellular Therapy and Transplantation
%D 2010
%I 
%X Hematopoietic stem cell transplantation is the only modality that offers the potential of cure for severe thalassemia, including homozygous ¦Â-thalassemia and severe Hb E/¦Â-thalassemia. All children with class 1 or 2 disease should be transplanted if they have HLA-identical siblings, and transplantation should be performed as early as possible. Sibling cord blood transplantation is recommended in children with class 1 or 2 of the disease if adequate numbers of cord blood cells from younger siblings are available.Bone marrow transplantation in class 3 children and adult patients with appropriate conditioning regimen gives results that are superior to those obtained with cord blood. However, we recommend that patients and their families should discuss in detail the risks and benefits, and transplantation should be performed in only motivated patients who have a clear understanding of the entire process. There is new hope that haploidentical transplantation will be successful, but further studies are required to confirm early results.
%K thalassemia
%K clinical risk factors
%K hematopoietic stem cell transplantation
%K indications
%K benefits
%U http://www.ctt-journal.com/index.php?id=410