%0 Journal Article
%T Integrin ¦Á5¦Â1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors
%A Florence Schaffner
%A Anne Marie Ray
%A Monique Dontenwill
%J Cancers
%D 2013
%I MDPI AG
%R 10.3390/cancers5010027
%X Integrins are transmembrane heterodimeric proteins sensing the cell microenvironment and modulating numerous signalling pathways. Changes in integrin expression between normal and tumoral cells support involvement of specific integrins in tumor progression and aggressiveness. This review highlights the current knowledge about ¦Á5¦Â1 integrin, also called the fibronectin receptor, in solid tumors. We summarize data showing that ¦Á5¦Â1 integrin is a pertinent therapeutic target expressed by tumoral neovessels and tumoral cells. Although mainly evaluated in preclinical models, ¦Á5¦Â1 integrin merits interest in particular in colon, breast, ovarian, lung and brain tumors where its overexpression is associated with a poor prognosis for patients. Specific ¦Á5¦Â1 integrin antagonists will be listed that may represent new potential therapeutic agents to fight defined subpopulations of particularly aggressive tumors.
%K ¦Á5¦Â1
%K integrin
%K fibronectin receptor
%K solid tumors
%K angiogenesis
%K antagonists
%U http://www.mdpi.com/2072-6694/5/1/27