%0 Journal Article
%T Divergent Roles of Autophagy in Virus Infection
%A Abhilash I. Chiramel
%A Nathan R. Brady
%A Ralf Bartenschlager
%J Cells
%D 2013
%I MDPI AG
%R 10.3390/cells2010083
%X Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens, viruses exploit and manipulate different host cell processes, including cellular trafficking, metabolism and immunity-related functions, for their own survival. In this article, we review evidence for how autophagy, a highly conserved cellular degradative pathway, serves either as an antiviral defense mechanism or, alternatively, as a pro-viral process during virus infection. Furthermore, we highlight recent reports concerning the role of selective autophagy in virus infection and how viruses manipulate autophagy to evade lysosomal capture and degradation.
%K selectively autophagy
%K virophagy
%K antiviral and proviral autophagy
%U http://www.mdpi.com/2073-4409/2/1/83