%0 Journal Article
%T Synthesis of azido derivatives of mucobromic acid
%A N. D. Jumbam
%A W. Masamba
%A N. Mbebe
%J Bulletin of the Chemical Society of Ethiopia
%D 2013
%I Chemical Society of Ethiopia
%X Mucobromic acid is a highly reactive multicentered molecule. It was converted to its corresponding but unstable diazido derivative by reaction with two equivalents of sodium azide. The resultant 3,4-diazido-5-hydroxyfuran-2(5H)-one was obtained in moderate yield (42%) but decomposed readily even at low temperatures. Its more stable analogue 3,4-diazido-5-methoxyfuran-2(5H)-one was obtained in excellent yield after reacting 5-methoxy-3,4-dibromofuranone with two equivalents of sodium azide. The 4,5-dibromopyridazinones which are in effect masked mucobromic acid derivatives, underwent nucleophilic substitution reactions with various nucleophiles, including azides and afforded corresponding azidopyridazinones in good yields. The synthesized azido-furanone and pyridazinone derivatives are earmarked for click reactions.DOI: http://dx.doi.org/10.4314/bcse.v27i1.17
%K 3
%K 4-Diazido-5-hydroxyfuran-2(5H)-one
%K 3
%K 4-diazido-5-methoxyfuran-2(5H)-one
%K 4
%K 5-Diazidopyridazinones
%K Mucobromic acid
%U http://www.ajol.info/index.php/bcse/article/view/84087