%0 Journal Article
%T Advances on Driver Oncogenes of Lung Adenocarcinoma
%A Jinghui WANG
%A Zongde ZHANG
%A Shucai ZHANG
%J Chinese Journal of Lung Cancer
%D 2013
%I Chinese Anti-Cancer Association; Chinese Antituberculosis Association
%R 10.3779/j.issn.1009-3419.2013.02.06
%X The adenocarcinoma of the lung has recently shown peculiar molecular characteristics, which relate with both carcinogenesis and response to targeted drugs. Several molecular alterations have been defined as ˇ°driver oncogenesˇ± responsible for both the initiation and maintenance of the malignancy. So far, 50% of lung adenocarcinoma has been found harbouring driver oncogenes, in which epidermal growth factor receptor pathway plays important roles. In this review, we will report mainly the advances on significance of some latest driver mutations.
%K Lung neoplasms
%K Adenocarcinoma
%K Oncogenes
%U http://dx.doi.org/10.3779/j.issn.1009-3419.2013.02.06