%0 Journal Article
%T Advanced Research of mTOR and Lung Carcinoid Tumors
%A Zixuan ZHANG
%A Mengzhao WANG
%J Chinese Journal of Lung Cancer
%D 2013
%I Chinese Anti-Cancer Association; Chinese Antituberculosis Association
%R 10.3779/j.issn.1009-3419.2013.01.08
%X Mammalian target of rapamycin (mTOR), a main protein kinase in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signaling pathway, is an important intracellular mediator involved in multiple celluar functions including proliferation, differentiation, apoptosis, tumorigenesis, and angiogenesis. Recently, the high expression of mTOR and mTOR-related kinase have been found in neuroendocrin tumors. Therefore, mTOR pathway represents an attractive target for new anticancer therapies except surgery.
%K Lung carcinoid tumors
%K Mammalian target of rapamycin
%K Medical treatment
%U http://dx.doi.org/10.3779/j.issn.1009-3419.2013.01.08