%0 Journal Article
%T Castleman¡¯s Disease: A Study of A Rare Lymphoproliferative Disorder In A University Hospital
%A Ibrahiem Saeed Abdul-Rahman
%A Ali M. Al-Amri
%A Khalid Qassim Ghallab
%J Clinical Medicine : Blood Disorders
%D 2009
%I 
%X Castleman¡¯s disease (CD) is a group of rare lymphoproliferative disorders sharing characteristic clinical and histological features, and usually accompanied by a marked systemic inflammatory response. Three histological patterns of lymph nodes were described: the hyaline-vascular, the plasma-cell and the mixed types. The former is more common (80%¨C90%) and tends to be localized. The plasma cell type is more aggressive and usually multicentric. It is interesting that the inflammatory manifestations seem to be related to a lymph node lesion, because the systemic symptoms and inflammatory activity can return to normal after surgical excision or successful medical treatment of the disease. We report here our 15-year experience with this rare disease in King Fahd Hospital of the University, Al-Khobar, Saudi Arabia, focusing on the clinical features, therapy, and patients¡¯outcome.
%K Castleman¡¯s disease
%K hyaline vascular
%K plasma cell
%K multicentric
%K polyclonal gammopathy
%K IL-6
%K Kaposi¡¯s sarcoma
%K HHV-8
%U http://www.la-press.com/castlemanrsquos-disease-a-study-of-a-rare-lymphoproliferative-disorder-a1530