%0 Journal Article
%T A Comparison of Clinicopathological Features and Molecular Markers in British and Nigerian Women with Breast Cancer
%A Isaac D. Gukas
%A Anne C. Girling
%A Barnabas. M. Mandong
%A Wendy Prime
%J Clinical Medicine : Oncology
%D 2008
%I 
%X Background: Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study¡¯s aim was to look for evidence of differences in tumour biology between the two cohorts.Methods: This study compared the stage, grade and pathological expression of  ve immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n = 34) and British (n = 34) breast cancer patients were retrieved from histology tissue banks.Results: There were signi cant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no signi cant differences were observed for tumour grade.Conclusion: There was a signi  cantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely in uence prognosis between Nigerian and British women with breast cancer
%K breast cancer
%K nigerian
%K immunocytochemistry
%K molecular markers
%U http://la-press.com/article.php?article_id=747