%0 Journal Article
%T Oxaliplatin for Metastatic Colon Cancer in a Patient with Renal Failure
%A Kenji Katsumata
%A Tetsuo Sumi
%A Tatehiko Wada
%A Yasuharu Mori
%J Clinical Medicine : Oncology
%D 2008
%I 
%X Objective: Oxaliplatin, a key part of the standard regimen for colorectal cancer in Western countries, has become available in Japan. In a hemodialysis patient with cecal cancer, we investigated the effi cacy, safety, pharmacokinetics, and dialysability of oxaliplatin.Methods: A 65-year-old man who had cecal cancer was treated with oxaliplatin (40 mg/m2) and l-leucovorin(l-LV) (200 mg/m2), which were administered simultaneously over 120 min via the side and main arms of a Y-tube, respectively. Then 5-FU (400 mg/m2) was administered rapidly via the side tube, followed by 5-FU (2,000 mg/m2) over 46 hours via the main tube. The patient had chronic renal failure due to diabetic nephropathy and hemodialysis was performed 3 times a week. Blood samples were collected from the dialyzer before and after each hemodialysis session to examine platinum clearance.Results: The patient received 3 courses of oxaliplatin before he died of cancer. During hemodialysis, the platinum level fell from 0.32 ¦Ìg/mL to 0.15 ¦Ìg/mL.Conclusion: Since patients with renal failure have various associated disorders and oxaliplatin has a long half-life, it is necessary to obtain more pharmacokinetic data to investigate its accumulation and dialysability during long-term treatment. Such data will assist in treating the rapidly increasing number of hemodialysis patients with colorectal cancer.
%K colorectal cancer
%K renal failure
%K oxaliplatin
%K hemodialysis
%U http://la-press.com/article.php?article_id=538