%0 Journal Article
%T Uptake of Cystatin by Melanoma Cells in Culture
%A Lauren Deady
%A James L. Cox
%J CellBio
%P 64-69
%@ 2325-7792
%D 2013
%I Scientific Research Publishing
%R 10.4236/cellbio.2013.22008
%X <p class=\"MsoNormal\">
	<span lang=\"EN-US\">The cystatins are a super</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">family of cysteine
protease inhibitors</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">which are ubiquitous in their biologic occurrence. Cystatin C, a
type II cystatin, is primarily a secreted protein found in most biological
fluids. Besides acting as inhibitors of cathepsin, the cystatins have been
found to have some non-inhibitor related functions and multiple physiological
roles.</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">Much interest has been generated for the cystatins as metastasis</span><span lang=\"EN-US\"> ¡°</span><span lang=\"EN-US\">suppressor</span><span lang=\"EN-US\">-</span><span lang=\"EN-US\">like</span><span lang=\"EN-US\">¡±</span><span lang=\"EN-US\"> proteins,
as they have been shown to inhibit metastasis for multiple cancer types. The
sites and actions of the cystatins related to tumor suppressor actions are
still unclear, however. In this work</span><span lang=\"EN-US\">,</span><span lang=\"EN-US\"> we have examined the uptake of cystatin by
metastatic melanoma cells in culture. Our results indicate cystatin uptake is
mediated by a non-canonical</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">endocytotic pathway in B16 murine melanoma
cells.</span><span lang=\"EN-US\"><o:p></o:p></span> 
</p>
%K Cystatin
%K Melanoma
%K Endocytosis
%K Fluorescent
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=32649