%0 Journal Article
%T Feasibility and Field Performance of a Simultaneous Syphilis and HIV Point-of-Care Test Based Screening Strategy in at Risk Populations in Edmonton, Canada
%A Joshua Bergman
%A Jennifer Gratrix
%A Sabrina Plitt
%A Jayne Fenton
%A Chris Archibald
%A Tom Wong
%A Ameeta E. Singh
%J AIDS Research and Treatment
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/819593
%X Few studies have evaluated the feasibility of delivering syphilis point-of-care (POC) testing in outreach (nonclinical) settings in resource rich countries. The objectives of the study were to evaluate the feasibility and diagnostic performance of performing both HIV and syphilis POC testing in outreach settings and to document new cases identified in the study population. 1,265 outreach testing visits were offered syphilis and HIV POC testing and 81.5% ( ) consented to testing. In our population, the SD Bioline 3.0 Syphilis Test had a sensitivity of 85.3% [CI (68.9每95.0)], specificity of 100.0% [CI (99.6每100.0)], positive predictive value (PPV) of 100.0% [CI (88.1每100.0)], and negative predictive value (NPV) of 99.5% [CI (98.9每99.8)]. Test characteristics for the INSTI HIV-1/HIV-2 Antibody Test had a 100.0% sensitivity [CI (39.8每100.00], 99.8 specificity [CI (99.3每100)], 66.7% PPV [CI (22.3每95.7)], and 100.0% NPV [CI (99.6每100.0)]. Four new cases of syphilis and four new HIV cases were diagnosed. In summary, at risk population seeking STI testing found POC tests to be acceptable, the POC tests performed well in outreach settings, and new cases of syphilis and HIV were identified and linked to treatment and care. 1. Introduction In the late 1990s, Canada appeared to be on the verge of eliminating syphilis, as all but one province/territory had achieved rates of less than 0.5 per 100,000 population in 1997 [1]. In 2001, the reported rate of infectious syphilis started to increase rapidly, particularly among men, related to outbreaks occurring in large urban centres across Canada [2]. The majority of outbreaks across Canada have occurred among men who have sex with men (MSM) and individuals involved in sex trade, but other outbreaks have occurred among heterosexual persons not reporting risks associated with either of these populations [2, 3]. Between 1999 and 2008, the province of Alberta experienced the largest increase in the reported rate of infectious syphilis in Canada and resulted in the province declaring a syphilis outbreak in March 2007 [2, 4]. The reported rate of infectious syphilis in Edmonton, the second largest urban municipality in Alberta and with a population of over one million people for the census metropolitan area, was 8.1 per 100,000 in 2009, higher than the provincial rate of 7.4 per 100,000 [5]. The majority of cases in this ongoing outbreak were in heterosexual persons, but vulnerable populations such as MSM, people of aboriginal descent, sex workers, and people who inject drugs (IDU) have been disproportionately affected [5, 6].
%U http://www.hindawi.com/journals/art/2013/819593/