%0 Journal Article
%T Reference Ranges for Serum Uric Acid among Healthy Assamese People
%A Madhumita Das
%A N. C. Borah
%A M. Ghose
%A N. Choudhury
%J Biochemistry Research International
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/171053
%X This study was designed to establish reference ranges for serum uric acid among healthy adult Assamese population. Samples from 1470 aged 35¨C86 years were used to establish age and sex related reference range by the centile method (central 95 percentile) for serum uric acid level. There were 51% ( ) males and 49% ( ) females; 75.9% ( ) of them were from urban area and the rest 24.1% ( ) were from the rural area. Majority of the population were nonvegetarian (98.6%, ) and only 1.4% ( ) were vegetarian. The mean age, weight, height, and uric acid of the studied group were years, £¿kg, £¿cm, and £¿mg/dL, respectively. There is a statistically significant difference in the mean value of the abovementioned parameters between male and female. The observed reference range of uric acid in the population is 2.6¨C8.2£¿mg/dL which is wider than the current reference range used in the laboratory. Except gender ( ), we did not find any significant relation of uric acid with other selected factors. 1. Introduction Serum uric acid (SUA) is the major end product of purine metabolism in humans; and the level of SUA is rigorously controlled by the balance between uric acid production and excretion [1]. A number of previous studies have reported the relationship between hyperuricemia and various cardiovascular diseases and their risk factors, including metabolic syndrome (MS). According to the earlier studies, not only frank hyperuricemia but also SUA levels almost within the normal range showed a positive correlation with MS [2, 3]. Recent studies have shown that SUA level is significantly associated with nonalcoholic fatty liver disease [4¨C6]. The current ¡°reference¡± or ¡°normal range¡± set for hyperuricemia often fails to identify patients with potential metabolic disorders [7]. The recommended criteria to be used for selection of subjects as source for reference values, the description of the specimen collection conditions [8], and the statistical terminology for description of these values have recently been outlined in human medicine [9]. The approach in developing reference values has been regarded as an important step towards clinical interpretation of laboratory data [10]. The clinician must of course weigh together the history, clinical signs, disease incidence, and so forth with the laboratory data [11¨C13]. Most of the medical laboratories used to quote ¡°normal ranges¡± not so related, but ideally test results of the biochemical parameters should be referred to as a population whose status is defined [14, 15]. The reference range of a particular parameter is defined as
%U http://www.hindawi.com/journals/bri/2014/171053/