%0 Journal Article %T Preparation, Characterization, and Antimicrobial Activities of Bimetallic Complexes of Sarcosine with Zn(II) and Sn(IV) %A Yasir Arafat %A Saqib Ali %A Saira Shahzadi %A Muhammad Shahid %J Bioinorganic Chemistry and Applications %D 2013 %I Hindawi Publishing Corporation %R 10.1155/2013/351262 %X Heterobimetallic complexes of Zn(II) and Sn(IV) with sarcosine have been synthesized at room temperature under stirring conditions by the reaction of sarcosine and zinc acetate in 2£¿:£¿1 molar ratio followed by the stepwise addition of CS2 and organotin(IV) halides, where R£¿=£¿Me, n-Bu, and Ph. The complexes were characterized by elemental analysis, FT-IR and NMR (1H, 13C) spectroscopy. IR data showed that the ligand acts in a bidentate manner. NMR data revealed the four coordinate geometry in solution state. In vitro antimicrobial activities data showed that complexes (3) and (4) were effective against bacterial and fungal strains with few exceptions. 1. Introduction Organotin compounds are amongst the most widely used organometallic compounds. Over the last several decades, they have been utilized for a variety of industrial and agricultural applications including pesticides, fungicide, and antifouling agents [1]. In general, the biochemical activity of organotin(IV) carboxylates is greatly influenced by the structure of the molecule and the coordination number of the tin atom [2, 3]. Therefore, the recognition of the importance between the biological properties and the structure of organotin(IV) carboxylates [4] has stimulated the study of carboxylates of tin. The diverse structural motifs are known in organotin compounds and attributed to the ambidentate character of the carboxylate ligands [5]. Steric and electronic attributes of organic substituents on tin and/or the carboxylate moiety impart significant influence on the structural characteristics in tin carboxylates. Therefore, synthesis of new organotin carboxylates with different structural features will be beneficial in the development of pharmaceutical organotin and in other properties and applications. Meanwhile, dithiocarbamate (DTC) is the ligand which strongly bonds with metal ions and can stabilize metal complexes with high oxidation number [6]. Organotin(IV) dithiocarbamate complexes have been widely studied due to Sn-S bond in their structure and the effects of the bonding on diversified applications basically in biological field [7, 8]. Zinc chloride is chiefly used as a catalyst for the Fischer indole synthesis and Friedel-Craft acylation reaction that was involved in the synthesis of organic£¿£¿compounds used in the laboratory [9]. The medical applications of Zn(II) compounds include treatments of parasitic diseases (eczema, ringworm, fungus, and athletes foot), and in many biological processes zinc plays an important role as metalloenzymes in which Zn(II) is coordinated by a ligand %U http://www.hindawi.com/journals/bca/2013/351262/