%0 Journal Article
%T Syntheses, Spectral Characterization, and Antimicrobial Studies on the Coordination Compounds of Metal Ions with Schiff Base Containing Both Aliphatic and Aromatic Hydrazide Moieties
%A Dinesh Kumar
%A Silky Chadda
%A Jyoti Sharma
%A Parveen Surain
%J Bioinorganic Chemistry and Applications
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/981764
%X An EtOH solution of 3-ketobutanehydrazide and salicylhydrazide on refluxing in equimolar ratio forms the corresponding Schiff base, LH3 (1). The latter reacts with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Zr(OH)2(IV), MoO2(VI), and UO2(VI) ions in equimolar ratio and forms the corresponding coordination compounds, [M(LH)(MeOH)3] (2, M = Mn, Co, Ni), [Cu(LH)]2 (3), [M¡ä(LH)(MeOH)] (4, M¡ä = Zn, Cd), [Zr(OH)2(LH)(MeOH)2] (5), [MoO2(LH)(MeOH)] (6), and [UO2(LH)(MeOH)] (7). The coordination compounds have been characterized on the basis of elemental analyses, molar conductance, spectral (IR, reflectance, 1H NMR, ESR) studies, and magnetic susceptibility measurements. They are nonelectrolytes in DMSO. The coordination compounds, except 3, are monomers in diphenyl. They are active against gram-positive bacteria (S. aureus, B. subtilis), gram-negative bacteria (E. coli, P. aeruginosa), and yeast (S. cerevisiae, C. albicans). 1 acts as a dibasic tridentate ONO donor ligand in 2¨C7 coordinating through its both enolic O and azomethine N atoms. The coordination compounds 2 and 3 are paramagnetic, while rest of the compounds are diamagnetic. A square-planar structure to 3, a tetrahedral structure to 4, an octahedral structure to 2, 6, and 7, and a pentagonal bipyramidal structure to 5 are proposed. 1. Introduction Aroyl hydrazones and their coordination compounds are known to possess the biological activities and inhibit many enzymatic reactions in the cell. Owing to their biological activities such as antifungal, antibacterial, antimycobacterial, antitumor, anti-inflammatory, anti-HIV, leishmanicidal, trypanocidal, inhibitor of anthrax lethal factor, antidiabetic, antimalarial, and antipyretic, there has been an increasing interest towards the studies of the coordination compounds of the Schiff bases containing the hydrazone moiety during the past few decades [1¨C12]. The coordination compounds containing hydrazone moiety have been reported to act as analytical reagents, such as polymer coatings, fluorescent materials [13, 14], enzymes inhibitors, antifungal/antibacterial agents [15, 16], and corrosion inhibitors [17]. A perusal of the literature reveals that much work has been carried out towards the coordination compounds of Schiff bases containing salicylhydrazide moiety [18¨C27]; however, no work seems to be reported on the coordination compounds of Schiff base derived from 3-ketobutanehydrazide and salicylhydrazide. Novel noncytotoxic salicylhydrazide-containing 1N inhibitors have been developed through substructure database search methods [28]. The
%U http://www.hindawi.com/journals/bca/2013/981764/