%0 Journal Article
%T Synthesis, Spectroscopic, and Biological Studies on New Zirconium(IV) Porphyrins with Axial Ligand
%A Gauri D. Bajju
%A Gita Devi
%A Sapna Katoch
%A Madhulika Bhagat
%A Deepmala
%A Ashu
%A Sujata Kundan
%A Sunil Kumar Anand
%J Bioinorganic Chemistry and Applications
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/903616
%X A series of parasubstituted tetraphenylporphyrin zirconium(IV) salicylate complexes (SA/5-SSAZr(IV)RTPP, R = p-H, p-CH3, p-NO2, p-Cl, SA = salicylate, and 5-SSA = 5-sulfosalicylate) have been synthesized, and the spectral properties of free base porphyrins, their corresponding metallated, and axially ligated zirconium(IV) porphyrin compounds were compared with each other. A detailed analysis of ultraviolet-visible (UV-vis), proton nulcear magnetic resonance (1H NMR) spectroscopy, infrared (IR) spectroscopy, and elemental analysis suggested the transformation from free base porphyrins to zirconium(IV) porphyrins. The ability of the metal in this complex for extra coordination of solvent molecules was confirmed by ESI-MS spectra. Besides the fluorescence, cyclic voltammetry, and thermogravimetric studies, the complexes were also screened for antimicrobial and anticancer activities. Among all the complexes, 5-SSAZr(p-NO2TPP) shows high antibacterial activity. 1. Introduction Synthesis and functionalization of porphyrins [1] have long been of great interest in the chemistry community because of the vast potentials and demands for porphyrin derivatives in diverse fields, such as materials [2, 3], supramolecular chemistry [4, 5], biomimetic models [6], catalysis [7, 8], photodynamic therapy [9], and ionophores [10]. Porphyrins were reported to exhibit a variety of biological activities. This is due to the fact that natural and synthetic porphyrins have relatively low toxicity in vitro and in vivo and they possess antitumor [11, 12] and antioxidant effects [13, 14] and have a good potential for metal ions complexation. The ability for numerous chemical modifications and the large number of different mechanisms by which porphyrins affect microbial and viral pathogens place porphyrins into a group of compounds with an outstanding potential for discovery of novel agents, procedures, and materials active against pathogenic microorganisms [15]. Metalloporphyrins are the basis of new antifungal, antiparasitic, and anticancer drugs because modification of the porphyrin periphery confers qualitatively a new spectrum of activities to metalloporphyrins [16, 17]. It has been reported that metal complexation alters the various physiological properties, especially the cytotoxic and antitumor activities, of many naturally occurring compounds. Zirconium(IV) porphyrins have gained attention from global researchers due to the peculiar characteristics of this class of compounds. To the best of our knowledge, the chemistry of zirconium(IV) porphyrinates remains underdeveloped,
%U http://www.hindawi.com/journals/bca/2013/903616/