%0 Journal Article
%T Synthesis, Spectral, and In Vitro Antibacterial Studies of Organosilicon(IV) Complexes with Schiff Bases Derived from Amino Acids
%A Har Lal Singh
%A Jangbhadur Singh
%A A. Mukherjee
%J Bioinorganic Chemistry and Applications
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/425832
%X The present work stems from our interest in the synthesis, characterization, and antibacterial evaluation of organosilicon(IV) complexes of a class of amino-acid-based Schiff base which have been prepared by the interaction of ethoxytrimethylsilane with the Schiff bases (N OH) in 1ˋ:ˋ1 molar ratio. These complexes have been characterized by elemental analysis, molar conductance, and spectroscopic studies including electronic IR and NMR (1H, 13C, and 29Si) spectroscopy. The analytical and spectral data suggest trigonal bipyramidal geometry around the silicon atom in the resulting complexes. The ligands and their organosilicon complexes have also been evaluated for in vitro antimicrobial activity against bacteria (Bacillus cereus, Nocardia spp., E. aerogenes, Escherichia coli, Klebsiella spp., and Staphylococcus spp.). The complexes were found to be more potent as compared to the ligands. 1. Introduction In the last decade, coordination and organometallic compounds of biologically active ligands [1每3] have received much attention. However, it is notable that the biological activity of Schiff bases was significantly enhanced on chelation. It has been reported that chelation is the cause and cure of many diseases including cancer. Schiff base complexes [4每7] have found antibacterial, antifungal, anticancer, tuberculostatic, and herbicidal activities [8每12]. The current research dealing with metal complexes of heteronuclear Schiff bases has expanded enormously and includes diversified subjects comprising their various aspects in biocoordination and bioinorganic chemistry. It is known that the presence of metal ions bonded to biologically active compounds may enhance their activity [13每16]. Heteronuclear Schiff base complexes have found applications as magnetic materials, catalysts and in the field of bioengineering [17, 18]. Organosilicon compounds of nitrogen and sulphur containing ligands are well known for their anticarcinogenic, antibacterial, tuberculostatic, antifungal, insecticidal, and acaricidal activities [19每22]. The interest in organosilicon(IV) compounds [23每25] is due to their versatile applicability in the pharmaceutical industries. Generally, organosilicon compounds seem to owe their antitumour properties to the immune-defensive system of the organism. The medical applications and effectiveness of the silatranes in the treatment of wounds and tumours are thought to be related to the role of silicon in the growth of epithelial and connective tissues and hair, where their function is to impart strength, elasticity, and impermeability to water
%U http://www.hindawi.com/journals/bca/2013/425832/