%0 Journal Article
%T Restorative Prospective of Powdered Seeds Extract of Garcinia kola in Chrysichthys furcatus Induced with Glyphosate Formulation
%A T. O. Ikpesu
%A I. Tongo
%A A. Ariyo
%J Chinese Journal of Biology
%D 2014
%R 10.1155/2014/854157
%X Responses of Chrysichthys furcatus to glyphosate formulation and Garcinia kola seed extracts were investigated using the organization for Economic Cooperation and Development numbers 203 and 407 recommended toxicity bioassay. The fish were divided into five groups and exposed to different treatments of glyphosate formulation and Garcinia kola seed extract, with the control serving as a reference. Water quality parameters and blood chemistry were estimated in the experimental and control fish at the end of 28 days. There was no significant difference ( ) between fish treated with glyphosate formulation alone and other treatments except for dissolved oxygen which was highly significant ( ) between fish treated with glyphosate formulation alone and other treatments and the control. All the blood parameters were significantly ( ) affected by glyphosate formulation when compared with the control. The changes observed in glyphosate formulation alone were reversible when G. kola seeds extract was added and was dose dependent. The plant¡¯s extract has shown to be a good remedy to pollutants, and formulations of the seed extract into tablets or capsules could serve as antidote to ameliorate the effects of pollutants. This finding can reduce the risk of biomagnifications of poisons along the food chain. 1. Introduction In the last few years there has been an exponential growth in the field of herbal medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects [1]. Herbal products cause few adverse effects but have beneficial pharmacological and therapeutic uses in a number of illnesses, including HIV where they have been examined for their capacity to reduce symptoms and improve quality of life [2]. The literature review had shown that oral administration of an aqueous T. cordifolia root extract to alloxan diabetic rats caused a significant reduction in blood glucose and brain lipids. Though the aqueous extract at a dose of 400£¿mg/kg could elicit significant antihyperglycemic effect in different animal models, its effect was equivalent to only one unit/kg of insulin [3]. It is reported that the daily administration of either alcoholic or aqueous extract of T. cordifolia decreases the blood glucose level and increases glucose tolerance in rodents [4]. Also, oral administration of 2 and 8£¿g/kg of plant extract of fenugreek seeds produced dose dependent decrease in the blood glucose levels in both normal diabetic rats [5]. The plant¡¯s seed extract also improved glucose metabolism and
%U http://www.hindawi.com/journals/cjb/2014/854157/