%0 Journal Article
%T Association between Obesity, Serum Lipids, and Colorectal Polyps in Old Chinese People
%A Wen Yang
%A Yan Chang
%A Haiyan Huang
%A Yuzhu Wang
%A Xiaohong Yu
%J Gastroenterology Research and Practice
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/931084
%X Background. Colorectal cancer mostly arises from the polyps of colon. The aim of our study was to examine the association of body mass index (BMI) and serum lipids with the colorectal polyps in old Chinese people. Methods. The risk of developing colorectal polyps was studied in 244 subjects (212 men and 32 women, 74.63 ¡À 11.63 years old) who underwent colonoscopy for the first time from January 2008 to July 2012 at the Navy General Hospital, Beijing, China. According to the results of colonoscopy, all the subjects were divided into 112 normal control, 38 right colorectal polyps, 53 left colorectal polyps, and 41 both right and left colorectal polyps groups. The total plasma cholesterol, plasma triglyceride, plasma creatinine concentration, blood urinary nitrogen, and fasting glucose were determined using a multichannel analyzer. Results. There were significant differences among normal control, right colorectal polyps, left colorectal polyps, and both right and left polyps groups, which were the BMI, total cholesterol, triglycerides, creatinine, and urinary nitrogen. In binary logistic regression analysis, there were two risk factors associated with the occurrence of colorectal polyps, which included BMI and systolic blood pressure. Conclusions. Colorectal polyps were significantly associated with increased BMI, total cholesterol, and triglycerides levels. 1. Introduction According to a report of the World Health Organization, cancer was the leading cause of death in 2007, accounting for 7.9 million deaths, or 13% of the total amount. The same report stated that colorectal cancer was the fourth most common fatal cancer, after lung, stomach, and liver cancers [1]. Epidemiological evidence has shown that obesity is associated with an increased risk of mortality from cancers [2, 3]. In some studies, serum triglyceride [4¨C7] and cholesterol [8¨C10] levels are positively related to an increased risk of colorectal adenoma, while several investigators report an insignificant or even inverse relationship between serum lipids and colorectal adenoma [11¨C13]. The prevalence of obesity and dyslipidemia is rising dramatically in both developed and developing countries. Therefore, we examined the association between body mass index (BMI), serum lipids, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and colorectal polyps in relatively immobile resident of old Chinese people, hoping to provide useful information for preventing colorectal cancer. 2. Methods 2.1. Study Population The subjects comprised 244 individuals who underwent a routine screening
%U http://www.hindawi.com/journals/grp/2013/931084/