%0 Journal Article
%T Advances in Optical Adjunctive Aids for Visualisation and Detection of Oral Malignant and Potentially Malignant Lesions
%A Nirav Bhatia
%A Yastira Lalla
%A An N. Vu
%A Camile S. Farah
%J International Journal of Dentistry
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/194029
%X Traditional methods of screening for oral potentially malignant disorders and oral malignancies involve a conventional oral examination with digital palpation. Evidence indicates that conventional examination is a poor discriminator of oral mucosal lesions. A number of optical aids have been developed to assist the clinician to detect oral mucosal abnormalities and to differentiate benign lesions from sinister pathology. This paper discusses advances in optical technologies designed for the detection of oral mucosal abnormalities. The literature regarding such devices, VELscope and Identafi, is critically analysed, and the novel use of Narrow Band Imaging within the oral cavity is also discussed. Optical aids are effective in assisting with the detection of oral mucosal abnormalities; however, further research is required to evaluate the usefulness of these devices in differentiating benign lesions from potentially malignant and malignant lesions. 1. Introduction Oral cancer affects the lips, tongue, gingiva, floor of mouth, palate, tonsils, and oropharynx [1¨C3]. It is ranked the sixth most common malignancy worldwide and is diagnosed at an increasing rate [4], with an estimated 263,900 new cases and 128,000 deaths in 2008 alone [5]. Oral squamous cell carcinoma (OSCC) can affect any tissue lined with oral mucosal epithelium and accounts for 90% of oral malignancies [1, 4]. Known aetiological risk factors for OSCC include tobacco, betel quid, alcohol, and micronutrient deficiency [2, 6, 7]; however, recent studies also implicate human papillomavirus (HPV) as a causative factor in cancers of the base of the tongue, tonsils, and oropharynx in patients without traditional risk factors [1, 2, 7]. Despite advances in cancer therapies, the five-year survival rate for oral cancer has remained at approximately 50% over the past three decades [4, 8]. This is primarily due to delayed diagnosis, with approximately half of all oral cancers diagnosed at stages III or IV [9]. By these stages, lymphatic spread has occurred and treatment is for a systemic condition rather than a localized disease process. Localised cancers have survival rates of up to 83% but this falls to 32% once tumour metastasis has occurred [10]. As such, emphasis should be placed on earlier detection of oral cancers to improve patient survival rates. OSCC is often preceded by visible and histological changes in the oral mucosa. Conditions which have the potential to develop into malignancies are referred to as oral potentially malignant disorders (OPMDs) and these include leukoplakia,
%U http://www.hindawi.com/journals/ijd/2013/194029/