%0 Journal Article
%T Therapeutic Potential of Hydrazones as Anti-Inflammatory Agents
%A Anu Kajal
%A Suman Bala
%A Neha Sharma
%A Sunil Kamboj
%A Vipin Saini
%J International Journal of Medicinal Chemistry
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/761030
%X Hydrazones are a special class of organic compounds in the Schiff base family. Hydrazones constitute a versatile compound of organic class having basic structure (R1R2C=NNR3R4). The active centers of hydrazone, that is, carbon and nitrogen, are mainly responsible for the physical and chemical properties of the hydrazones and, due to the reactivity toward electrophiles and nucleophiles, hydrazones are used for the synthesis of organic compound such as heterocyclic compounds with a variety of biological activities. Hydrazones and their derivatives are known to exhibit a wide range of interesting biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective, anthelmintic, antidiabetic, antitubercular, trypanocidal, anti-HIV, and so forth. The present review summarizes the efficiency of hydrazones as potent anti-inflammatory agents. 1. Introduction Inflammation is a physiological reactionwhich involves cellular and biochemical responses, which is not only symptom for common diseases but also known to be an early phase for some serious diseases such as alzheimer¡¯s disease, cancer, heart vascular diseases [1] etc. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ketoprofen, ibuprofen, aceclofenac, and so forth under current clinical usage for the treatment of inflammation, algesia and pyresis [2] are associated with major drawbacks of gastrointestinal disorders like dyspepsia, gastric ulcers, and so forth, due to the direct contact of free carboxylic group with the gastric mucosa [3, 4] and due to decrease in production of prostaglandins in tissue [5]. In order to overcome these drawbacks, there is an urgent need for design and synthesis of new chemical entities with excellent anti-inflammatory response and minimum side effects. Hydrazones are a class of organic compounds in the Schiff base family [6]. Hydrazones constitute a versatile compound of organic class having the basic structure R1R2C=NNR3R4 [7, 8]. Two nitrogen atoms of hydrazone are nucleophilic but the amino type nitrogen is more reactive, whereas the carbon atom possesses both characters, that is, nucleophilic and electrophilic. The active centers of hydrazine, that is, carbon and nitrogen, are mainly responsible for the physical and chemical properties of the hydrazones and, due to the reactivity toward electrophiles and nucleophiles, hydrazones are used for the synthesis of organic compound such as heterocyclic compounds [9, 10]. The general method for the synthesis of
%U http://www.hindawi.com/journals/ijmc/2014/761030/