%0 Journal Article
%T Analgesic, Anti-Inflammatory, and Antiplatelet Profile of Hydrazones Containing Synthetic Molecules
%A Mohammad Asif
%A Asif Husain
%J Journal of Applied Chemistry
%D 2013
%R 10.1155/2013/247203
%X Hydrazones are present in many of the bioactive compounds with wide interest because of their diverse pharmacological applications. Hydrazones possess wide variety of biological activities such as anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimicrobial, anticancer, antihypertensive, anthelmintic, antidiabetic, antiparasitic, and other anticipated activities. This created an interest for researchers towards synthesized variety of hydrazone derivatives for different biological activities. Therefore many researchers have synthesized hydrazone derivatives as target structures for their biological activities. This is paper focuses on the analgesic, anti-inflammatory, and antiplatelet activities of hydrazones. 1. Introduction Hydrazones constitute an important class of biologically active drug molecules which has attracted the attention of medicinal chemists due to their wide range of pharmacological properties. These compounds are being synthesized as drugs by many researchers in order to combat diseases with minimal toxicity and maximal effects. These predictions have provided a therapeutic pathway to develop new effective biologically active hydrazones. A number of hydrazone derivatives have been reported to exert notably biological activities [1, 2]. Hydrazones possess an azomethine ¨CNHN=CH group which are considered as derivatives of aldehydes and ketones in which the oxygen atom has been replaced by the =NNH2 group. Hydrazones are of wide interest because of their diverse biological applications such as anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, anticancer, vasodilator, antiviral, anti-HIV, anthelmintic, antidiabetic, and trypanocidal activities [2¨C10]. The hydrazones are used as hole transporting agents in organic layer photoconductors, as quantitative analytical reagents, especially in colorimetric and fluorometric determination of metal ions [11¨C13]. Furthermore, some hydrazones have also been used as herbicides, insecticides, nematocides, rodenticides, and plant growth regulators as well as plasticizers and stabilizers for polymers. The metal complexes of hydrazones have potential applications as catalysts, luminescent probes, and molecular sensors [1, 14, 15]. A class of N-arylsulfonyl hydrazones has been developed as novel inhibitors of IMP-1, a metallo-¦Â-lactamase. As a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone, these compounds may serve as efficient inhibitors of IMP-1. Molecular
%U http://www.hindawi.com/journals/jac/2013/247203/