%0 Journal Article
%T Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects
%A Jaydip Ray Chaudhuri
%A K. Rukmini Mridula
%A Alluri Anamika
%A Demudu Babu Boddu
%A Pradeep Kumar Misra
%A A. Lingaiah
%A Banda Balaraju
%A Vcs Srinivasarao Bandaru
%J Journal of Lipids
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/623420
%X Background. Vitamin D deficiency is widespread throughout the world. Several reports have incriminated vitamin D deficiency as the cause of rickets, osteomalacia, and other chronic diseases. Recent studies have suggested a possible link between deficiency of 25-hydroxyvitamin D and dyslipidemia. Aim. To investigate the association between 25-hydroxyvitamin D deficiency and dyslipidemia in Indian subjects. Methodology. We recruited 150 asymptomatic consecutive subjects from patients¡¯ attendees at the Departments of Neurology and Medicine in Yashoda Hospital, Hyderabad, India. Study period was from October 2011 to March 2012. All subjects underwent 25-hydroxyvitamin D assay by chemiluminescent microparticle immunoassay, fasting blood sugar and lipid profile, calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP). Results. Out of 150 subjects, men were 82 (54.6%), and mean age was 49.4 (¡À15.6) years. Among risk factors, hypertension was noted in 63/150 (42%), 25-hydroxyvitamin D deficiency in 59/150 (39.3%), diabetes in 45/150 (30%), dyslipidemia in 60 (40%), smoking in 35/150 (23.3%), and alcoholism in 27/150 (18%). Deficiency of 25-hydroxyvitamin D was significantly associated with dyslipidemia ( ), mean serum glucose ( ) mean CRP ( ), and mean alkaline phosphatase ( ). Multivariate analysis showed that 25-hydroxyvitamin D deficiency was independently associated with dyslipidemia (odds ratio: 1.9; 95%£¿CI£¿:£¿1.1¨C3.5). Conclusions. We found that deficiency of 25-hydroxyvitamin D was independently associated with dyslipidemia in Indian subjects. 1. Introduction Vitamin D deficiency is a common disorder, found in all age groups and in both genders [1, 2]. It is prevalent in various parts of the world including India [1¨C3] with an increased occurrence in high and low latitude countries [4]. Worldwide, the prevalence of vitamin D deficiency is 50% in elderly [5] and within Europe in 2%¨C30% of adults [6]. Serum 25-hydroxyvitamin D level is a sensitive measure of vitamin D status of an individual [1], and the prevalence of inadequate 25-hydroxyvitamin D is around 30% to 50% in the general population [7]. Recent reports have found that hypo 25-hydroxyvitamin D is associated with atherosclerosis [8], obesity [9], diabetes [10], hypertension [11], myocardial infarction [12], and stroke [13]. Dyslipidemia is a an independent risk factor for cardiovascular and cerebrovascular diseases in individuals [14, 15]. Current studies have observed that low 25-hydroxyvitamin D is associated with dyslipidemia [16, 17]. We aim to investigate the relationship of
%U http://www.hindawi.com/journals/jl/2013/623420/