%0 Journal Article
%T Pulse-Wave Analysis of Optic Nerve Head Circulation Is Significantly Correlated with Kidney Function in Patients with and without Chronic Kidney Disease
%A Tomoaki Shiba
%A Mao Takahashi
%A Takatoshi Maeno
%J Journal of Ophthalmology
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/291687
%X Aim. To determine whether there is a significant correlation between the optic nerve head (ONH) circulation determined by laser speckle flowgraphy (LSFG) and kidney function. Materials. Seventy-one subjects were investigated. The estimated glomerular filtration rate (GFR) and serum creatinine, cystatin C, and urinary albumin excretion were measured. The ONH circulation was determined by an analysis of the pulse wave of LSFG, and this parameter was named blowout time (BOT). Chronic kidney disease (CKD) was defined to be present when the estimated GFR was <60£żmL/min per 1.73£żm2. PearsonĦŻs correlation coefficients were used to determine the relationship between the BOT and the kidney function. We also examined whether there were significant differences in all parameters in patients with and without CKD. Results. BOT was significantly correlated with the level of creatinine ( , ), the estimated GFR ( , ), cystatin C ( , ), and urinary albumin excretion ( , ). The BOT level in subjects with CKD was significantly lower than that in subjects without CKD ( ). Conclusion. BOT in ONH by LSFG can detect the organ damage such as kidney dysfunction, CKD. 1. Introduction Chronic kidney disease (CKD) is associated with high cardiovascular mortality [1¨C3]. More than 45% of predialysis CKD patients die with cardiovascular disease before reaching the end stage of kidney disease [4]. CKD has been defined as a creatinine-based estimated glomerular filtration rate (GFR) that is <60£żmL/min per 1.73£żm2 [5]. This represents a loss of more than one-half of normal renal function. An estimated GFR of <60£żmL/min per 1.73£żm2 has been strongly correlated with cardiovascular risk and death [3]. Other factors reflecting kidney function are the levels of serum cystatin C and urinary albumin excretion. Evaluations of serum cystatin C and serum creatinine were reported to predict cardiovascular events in elderly persons without chronic kidney disease [6]. In addition, urinary albumin excretion is a predictor of all causes of mortality in the general population [7]. However, the relationship between these kidney function parameters and ocular circulation remains unclear. Therefore, it was suggested that evaluations of the relationships between ocular circulation and kidney function are important, because kidney and eye reflect the peripheral circulation in both. Laser speckle flowgraphy (LSFG; Kyushu Institute of Technology, Fukuoka, Japan) is a method of determining ocular blood flow and is based on the changes in the speckle pattern of laser light reflected from the fundus of the eye
%U http://www.hindawi.com/journals/joph/2014/291687/