%0 Journal Article
%T Assessment of Myometrial Concentrations of Oestrogen and Progesterone Receptors in the Lower Uterine Segment of Full-Term Pregnancies in Presence or Absence of Labour
%A Joana Soares de Arruda
%A Edward Araujo J迆nior
%A Manuel de Jesus Simˋes
%A Luiz Kulay J迆nior
%J Journal of Pregnancy
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/213193
%X Objective. To assess the concentration of progesterone (PRs) and oestrogen (ORs) receptors of myometrium of full-term pregnant women in the myometrium of lower segment of the uterus in relationship with presence or absence of labour. Methods. This was a cross-sectional prospective study with 21 pregnant women, being 6 in labour (Group I) and 15 without labour (Group II). The biopsy of myometrium was realized during caesarian section, and the excised tissue was stained using immunohistochemical techniques for the quantification of the receptors, and with the aid of image-analysis software, the numbers of receptors for each hormone were determined spectrophotometrically. The Mann-Whitney test was used to compare the pregnant women in each study group with respect to the numbers of ORs and PRs. The Wilcoxon test was used to compare the concentration of ORs and PRs in each group separately. Results. The mean of gestational age was 39 weeks, (range, 37 to 41 weeks). The medians of PRs and ORs in pregnant women in labour (Group I) were 29.3 (range, 24.6每30.2) and 32.3 (range, 22.9每49.0), respectively. The medians of PRs and ORs in pregnant women without labour (Group II) were 43.6 (range, 23.6每70) and 43.9 (range, 18.3每62.6), respectively. We did not observe significant differences of the number of ORs and PRs in both groups ( and 0.37, resp.). The number of ORs was statistically more than that of PRs in Group II (Z calculatedˋ=ˋ16.00). Conclusion. The concentrations of PRs and ORs were similar in the myometrium of the lower uterine segment of pregnant women during and without labour, but the concentration of ORs was more than that of PRs in the myometrium of the lower uterine segment of pregnant women without labour. 1. Introduction Hormonal changes at the moment of parturition may constitute an important regulatory mechanism for myometrial contraction. In some species (e.g., sheep), sudden changes in circulating cortisol, oestrogen, and progesterone appear to be important factors for the onset of labour, whereas in humans, these signs remain unknown [1每10]. Therefore, we investigated the concentration of oestrogen receptors (ORs) and progesterone receptors (PRs) in pregnant human women because local modifications of these receptors may be associated with the myometrial conditions responsible for the mechanism of parturition [1每10]. Prior studies on hormone concentrations during labour have failed to demonstrate significant changes indicating their direct involvement in labour; however, local changes in hormone receptors are believed to be responsible for
%U http://www.hindawi.com/journals/jp/2013/213193/