%0 Journal Article
%T Feasibility of an Isometric Maximal Voluntary Contraction Test in Hematological Cancer Patients during Thrombocytopenia
%A Philipp Zimmer
%A Freerk T. Baumann
%A Janis Ebel
%A Eva Maria Zopf
%A Wilhelm Bloch
%A Thomas Elter
%J Journal of Sports Medicine
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/470489
%X Introduction. Resistance training is rarely offered to hemato-oncological patients in the daily clinical routine due to its potential harmful impact on the cardiovascular system and the long periods of thrombocytopenia experienced by these patients. Therefore, it is important to determine a valid assessment to define and control resistance training. In this study, the feasibility of a maximal voluntary contraction (MVC) test was investigated in hemato-oncological patients. This inexpensive assessment may be a practicable alternative to the one repetition maximum test which is currently described as the gold standard. Methods. 29 hemato-oncological patients with platelet counts between 30000/¦ÌL and 70000/¦ÌL were recruited for this pilot study. Complications like petechial bleedings, muscle convulsion, and pain were assessed using the Brief Pain Inventory before and 48 hours after the MVC test, which was performed unidirectionally for the quadriceps muscle. Results. We did not detect any statistically significant test-related exacerbations or pain development. Discussion. MVC testing seems to be a feasible method to control a resistance training program in hemato-oncological patients. Further studies need to extend their methods and, for example, compare the MVC test with the one repetition maximum test. 1. Introduction Hemato-oncological patients who underwent chemotherapy often show a severe reduction in muscle mass. This reduction may be caused by immobilization, the influence of chemotherapeutic agents, and/or the impact of immunosuppressive therapy consisting of glucocorticoids and cyclosporine and counteracting the graft-versus-host-disease [1¨C9]. The decrease of muscle mass leads to a loss of physical performance and is involved in certain cancer and therapy associated phenomena like cancer-related fatigue and cachexia [10, 11]. Especially patients suffering from cachexia have a poor prognosis and a reduced tolerance regarding intensive treatment protocols including radiation and chemotherapeutic agents [12]. The positive influence of different types of exercise, for example, endurance and resistance training, on physical and psychological outcomes in cancer patients has been proven in several studies [13¨C15]. Yet evidence-based guidelines regarding resistance training frequencies and intensities are still missing. Possibly more valid and practicable assessment methods would help to generate specific recommendations. Although leukemia and lymphoma patients have a comparably long hospitalization phase and therefore experience long periods of
%U http://www.hindawi.com/journals/jsm/2013/470489/