%0 Journal Article
%T Significance of Urinary Proteome Pattern in Renal Allograft Recipients
%A Sufi M. Suhail
%J Journal of Transplantation
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/139361
%X Urinary proteomics is developing as a platform of urinary biomarkers of immense potential in recent years. The definition of urinary proteome in the context of renal allograft and characterization of different proteome patterns in various graft dysfunctions have led to the development of a distinct science of this noninvasive tool. Substantial numbers of studies have shown that different renal allograft disease states, both acute and chronic, could portray unique urinary proteome pattern enabling early diagnosis of graft dysfunction and proper manipulation of immunosuppressive strategy that could impact graft prognosis. The methodology of the urinary proteome is nonetheless not more complex than that of other sophisticated assays of conventional urinary protein analysis. Moreover, the need for a centralized database is also felt by the researchers as more and more studies have been presenting their results from different corners and as systems of organizing these newly emerging data being developed at international and national levels. In this context concept of urinary proteomics in renal allograft recipients would be of significant importance in clinical transplantation. 1. Introduction Overt proteinuria is an established prognostic marker in renal allograft recipients associated with allograft dysfunction and graft loss [1, 2]. However, the early detection of the causes of graft dysfunction and graft loss is important. The current modality for definitive diagnosis of graft abnormalities is graft biopsy [3]. Inherent risk of biopsy on a single transplanted kidney and delay involved in the detailed reporting of the tissue could preclude an early diagnosis of the graft dysfunction and early institution of specific therapy. On the other hand, urinary proteome is a distinct entity from the conventional nosology of proteinuria that has been emerging in recent years [4, 5]. Urinary proteome constitutes the entire genomic protein content that is excreted in urine in health and disease states. Proteomic urine analysis could predict the diagnosis of renal transplant pathologies early, which could impact the graft function and survival in the long run [5]. Moreover, urinary proteome patterns in transplant patients could differentiate stable graft function from acute tubulointerstitial rejection (AR), urinary tract infection (UTI), acute tubular necrosis (ATN), and calcineurin inhibitor (CNI) toxicity [6]. In addition, characterization of chronic allograft dysfunction into chronic antibody associated rejection (CAAR), interstitial fibrosis tubular atrophy
%U http://www.hindawi.com/journals/jtrans/2014/139361/