%0 Journal Article
%T Renal Protective Effects of Resveratrol
%A Munehiro Kitada
%A Daisuke Koya
%J Oxidative Medicine and Cellular Longevity
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/568093
%X Resveratrol (3,5,4¡ä-trihydroxystilbene), a natural polyphenolic compound found in grapes and red wine, is reported to have beneficial effects on cardiovascular diseases, including renal diseases. These beneficial effects are thought to be due to this compound¡¯s antioxidative properties: resveratrol is known to be a robust scavenger of reactive oxygen species (ROS). In addition to scavenging ROS, resveratrol may have numerous protective effects against age-related disorders, including renal diseases, through the activation of SIRT1. SIRT1, an NAD+-dependent deacetylase, was identified as one of the molecules through which calorie restriction extends the lifespan or delays age-related diseases, and this protein may regulate multiple cellular functions, including apoptosis, mitochondrial biogenesis, inflammation, glucose/lipid metabolism, autophagy, and adaptations to cellular stress, through the deacetylation of target proteins. Previous reports have shown that resveratrol can ameliorate several types of renal injury, such as diabetic nephropathy, drug-induced injury, aldosterone-induced injury, ischemia-reperfusion injury, sepsis-related injury, and unilateral ureteral obstruction, in animal models through its antioxidant effect or SIRT1 activation. Therefore, resveratrol may be a useful supplemental treatment for preventing renal injury. 1. Introduction Chronic kidney disease (CKD),¡¡which is characterized by a¡¡chronic reduction in the glomerular filtration rate (GFR) and the presence of proteinuria or albuminuria, is recognized as an independent risk factor for both end-stage renal disease (ESRD) and cardiovascular disease, leading to a decrease in quality of life and an increased risk of mortality¡¡[1]. Acute kidney injury (AKI) is common in the setting of critical illness and is associated with a high risk of death¡¡[2]. In addition, AKI can directly cause ESRD and can increase the risks of the development of incident CKD and the worsening of underlying CKD¡¡[3]. Therefore,¡¡additional treatment to prevent¡¡both chronic and acute kidney injury is necessary. Resveratrol (3,5,4¡ä-trihydroxystilbene) is a polyphenolic¡¡phytoalexin that occurs naturally in many plant parts and products, such as grapes, berries, red wine, and peanut skins [4], and has¡¡numerous beneficial health effects. Previous epidemiological studies have revealed an inverse correlation between red wine consumption and the incidence of cardiovascular disease, a phenomenon known as the ¡°French Paradox.¡± The French population¡¡has relatively low rates of cardiovascular disease despite
%U http://www.hindawi.com/journals/omcl/2013/568093/