%0 Journal Article
%T Co-Occurrence of Arthritis and Stroke amongst Middle-Aged and Older Adults in Canada
%A Roman Matveev
%A Chris I. Ardern
%J Stroke Research and Treatment
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/651921
%X Arthritis is a chronic inflammatory condition commonly associated with mobility restriction and reduced activity. To date, the extent to which arthritis is an independent risk factor for stroke is unclear, and important, in light of an aging population. The purpose of this study was to (i) quantify the cross-sectional association between stroke and arthritis and (ii) to determine whether the relationship differed in physically active and inactivemiddle-aged and older adults. Data was derived from the 2010 Canadian Community Health Survey ( ≡30ˋy). Multivariable logistic regression was used to estimate the association between arthritis and stroke in models adjusted for age, physical activity (PA), and demographic factors. Overall, individuals with arthritis were 4 times more likely to report a history of stroke ( , 95% CI = 3.06每4.68), whereas those who were engaged in at least moderate PA (≡ˋ1.5ˋkcal/kg/day) were less than half as likely (0.45, 0.92ˋ0.62). This effect was moderated by age, as younger (30每65ˋy: 3.27, 2.22每4.83) but not older adults (>65ˋy: 1.04, 0.8每1.35) with arthritis had elevated odds of stroke. Both physical inactivity and arthritis are associated with higher odds of stroke, effects of which are the strongest amongst 30每65 year olds. 1. Introduction Stroke is a serious medical emergency and is the third leading cause of death in Canada [1]. Amongst the many known stroke risk factors, the INTERSTROKE study [2] identified 10 factors (including hypertension, smoking, alcohol intake, physical activity, diabetes, and cardiac causes) that are associated with 90% of all cases. While the stroke literature is extensive, few studies have examined the relationship of stroke to chronic diseases such as arthritis. Current estimates project that nearly 4 million Canadians are living with arthritis and that, by 2026, this number is expected to increase to over 6 million [3]. Subsequently, the direct and indirect healthcare burden of arthritis is considerable, particularly when estimates of work-related disability are included [4]. Given that older adults represent a large and growing proportion of the Canadian population [5], the issue of complex chronicity, such as the co-occurrence and interrelation of conditions such as arthritis and stroke, must be given greater attention. To date, research on the relationship between stroke and arthritis has been largely derived from studies of cardiovascular mortality [6]. A recent meta-analysis by Meune et al. [7] found that stroke was more commonly seen amongst individuals with rheumatoid arthritis (RA) (OR
%U http://www.hindawi.com/journals/srt/2014/651921/