%0 Journal Article
%T Cerebellar Cognitive Affective Syndrome Presented as Severe Borderline Personality Disorder
%A Danilo Pesic
%A Amir Peljto
%A Biljana Lukic
%A Maja Milovanovic
%A Snezana Svetozarevic
%A Dusica Lecic Tosevski
%J Case Reports in Medicine
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/894263
%X An increasing number of findings confirm the significance of cerebellum in affecting regulation and early learning. Most consistent findings refer to association of congenital vermis anomalies with deficits in nonmotor functions of cerebellum. In this paper we presented a young woman who was treated since sixteen years of age for polysubstance abuse, affective instability, and self-harming who was later diagnosed with borderline personality disorder. Since the neurological and neuropsychological reports pointed to signs of cerebellar dysfunction and dysexecutive syndrome, we performed magnetic resonance imaging of brain which demonstrated partially developed vermis and rhombencephalosynapsis. These findings match the description of cerebellar cognitive affective syndrome and show an overlap with clinical manifestations of borderline personality disorder. 1. Introduction There are an increasing number of findings supporting the fact that cerebellum, apart from its significance in movement coordination (sensomotoric cerebellum), plays an important role in cognitive and emotional regulation (cognitive and limbic cerebellum) [1]. In comparison with malformations of other parts of cerebellum and the acquired lesions, congenital vermis deficit presents as pronounced slow psychomotor development and worse cognitive functioning (lower IQ) and language skills, as well as affective dysregulation [2]. Rhombencephalosynapsis (RS) is a rare congenital posterior fossa malformation characterised by hypogenesis or agenesis of the vermis, dorsal fusion of cerebellar hemispheres, and fusion of the dentate nuclei and superior cerebellar peduncles [3]. This paper presents a case of a patient diagnosed with borderline personality disorder (BPD). Brain MRI, which was performed because of severe clinical picture and neurological and cognitive deficits, showed partially developed vermis and rhombencephalosynapsis. This sheds a new light on the severity of and nonresponsiveness to medication. 2. Case Report Unemployed, single, 26-year-old woman, with a qualification in catering industry, living with parents, was admitted for treatment to the Institute of Mental Health in Belgrade after one of her multiple suicide attempts by self-poisoning with benzodiazepines. She had been repeatedly hospitalized since she was 16, at first because of polysubstance abuse and later because of self-destructive behaviour, affective instability, and impulsiveness, and had been diagnosed with BPD. Over the past few years psychotropic medications were discontinued. However, she was unable to get a
%U http://www.hindawi.com/journals/crim/2014/894263/