%0 Journal Article
%T The Response of Circulating Leptin Levels to Exercise Stress Testing in Subjects Diagnosed with Metabolic Syndrome
%A Dana Pop
%A Alexandra D£¿darlat
%A Gyorgy Bodizs
%A Liana Stanca
%A Dumitru Zdrenghea
%J ISRN Endocrinology
%D 2014
%R 10.1155/2014/689260
%X Aim. To assess the plasma leptin responses after exercise stress testing in patients with metabolic syndrome (MS). Material and Methods. We investigated 67 patients with MS, with mean age of years. They underwent exercise stress testing on cycloergometer. The lot was divided into three groups: group 1¡ª10 patients with a true positive test, group 2¡ª18 patients with a true negative test, and group 3¡ª39 patients with a false negative test. Leptin levels were measured using the ELISA method. Results. Leptin levels decreased after effort in patients with MS ( £¿ng/mL before and £¿ng/mL after the exercise stress test, , ). In groups 1 ( at rest versus £¿ng/mL after the exercise test, ) and 3 ( at rest versus £¿ng/mL, ), lower leptin levels were recorded immediately after exercise testing. Leptin levels were not significantly lower in group 2 before effort ( £¿ng/ml) and after ( £¿ng/mL). We found no correlation between leptinemia and exercise stress testing parameters, regardless of group. Conclusion. Our research showed that short-term exercise lowers leptin levels in coronary patients, without a relationship between its parameters and leptin values. 1. Introduction Lately, the adipose tissue was found to be a major endocrine organ which secretes adipokines and cytokines, called adipocytokines. Recent studies have revealed the significant role of adipocytokines in the pathogenesis of obesity, metabolic syndrome, and cardiovascular disease [1]. Thereby, studies performed on humans and animals have shown that adiponectin, apelin, or omentin exerts antiatherogenic effects through various mechanisms, while leptin, resistin, and visfatin are associated with atherosclerosis [1]. So high leptin levels are involved not only in the appearance and progression of atherosclerosis but also in the development of arterial hypertension and metabolic syndrome [1]. The adipose tissue is mainly composed of adipocytes, which produce and release active biopeptides, known as adipokines or adipocytokines. Undoubtedly, adiponectin and leptin are the most widely studied adipokines. Leptin and other proteins, secreted by fat cells or macrophages, are found in large amounts in obese patients, whereas adiponectin levels are low. Recent data shows that adipokines and adipose tissue play a substantial role in the development of obesity, metabolic syndrome, cardiovascular disease, and atherosclerosis process [2¨C4]. Although the role of adipokines in the pathogenesis of cardiovascular disease is not yet fully understood, there is sufficient evidence that those could be important markers of this
%U http://www.hindawi.com/journals/isrn.endocrinology/2014/689260/