%0 Journal Article
%T T-Cell Receptor-Like Antibodies: Targeting the Intracellular Proteome Therapeutic Potential and Clinical Applications
%A Maya Cohen
%A Yoram Reiter
%J Antibodies
%D 2013
%I MDPI AG
%R 10.3390/antib2030517
%X Major histocompatibility complex (MHC) class I molecules are key in the immune response against malignant cells by shaping the T-cell repertoire and presenting peptides from endogenous antigens to CD8+ cytotoxic T cells. Because of their unique specificity, MHC-peptide complexes are a desirable target for novel immunotherapeutic approaches. These complexes can be targeted by recombinant T-cell receptors (TCRs). However, most TCRs produced thus far have affinities which are too low for target detection under normal assay conditions, and limited stability (due to their generation in a single-chain version). Developing high-affinity soluble antibody molecules endowed with a TCR-like specificity toward tumor epitopes, termed TCR-like antibodies, addresses the low affinity of TCRs. These TCR-like antibodies are being developed as a new immunotherapeutic class for targeting tumor cells and mediating their specific killing. In addition, these antibodies are valuable research reagents enabling the study of human class I peptide-MHC ligand-presentation and TCR¨Cpeptide¨CMHC interactions.
%K antibodies
%K antibody engineering
%K immunotoxins
%K MHC-peptide complex
%K phage display
%K recombinant antibodies
%K T-cell receptor
%K cancer immunotherapy
%U http://www.mdpi.com/2073-4468/2/3/517