%0 Journal Article
%T Influence of Sodium Lauryl Sulfate and Tween 80 on Carbamazepine每Nicotinamide Cocrystal Solubility and Dissolution Behaviour
%A Mingzhong Li
%A Ning Qiao
%A Ke Wang
%J Pharmaceutics
%D 2013
%I MDPI AG
%R 10.3390/pharmaceutics5040508
%X The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine每nicotinamide (CBZ每NIC) cocrystal solubility and dissolution behaviour has been studied in this work. The solubility of the CBZ每NIC cocrystal was determined by measuring the eutectic concentrations of the drug and the coformer. Evolution of the intrinsic dissolution rate (IDR) of the CBZ每NIC cocrystal was monitored by the UV imaging dissolution system during dissolution. Experimental results indicated that SLS and Tween 80 had little influence upon the solubility of the CBZ每NIC cocrystal but they had totally opposite effects on the IDR of the CBZ每NIC cocrystal during dissolution. SLS significantly increased the IDR of the CBZ每NIC cocrystal while Tween 80 decreased its IDR.
%K surfactant
%K carbamazepine每nicotinamide cocrystal
%K UV imaging
%K intrinsic dissolution rate
%K Raman spectroscopy
%U http://www.mdpi.com/1999-4923/5/4/508