%0 Journal Article %T The Polymorphism and Transformation of (3aRS, 4RS, 7RS, 7aSR)-2-(Tricyclo[3.3.1.13,7]decan-1-yl)-4,5,6,7-tetrahydro-4,7-eposyisoindoline-1,3-dione (SU2162)¡ªA Novel Anticancer Compound %A Yuqing Huang %A Zaiyou Tan %A Lin Luo %A Hui Yang %A Chunmei Tong %A Wenfei Chen %A Tingyu Huang %A Ruiling Liu %J Journal of Crystallization Process and Technology %P 27-30 %@ 2161-7686 %D 2014 %I Scientific Research Publishing %R 10.4236/jcpt.2014.41004 %X

Objective: To determine the transformation between two known crystal forms of the title compound (C18H23NO3, Mr = 301.37). Methods: To recrystallize or heat the crystals and determine the crystal form by testing the melting points. Results: Both the two known crystal forms of the title compound can be changed by dissolving into different organic solvents such as acetone and ethyl acetate. Crystal form I was not influenced by heating while crystal form II can be transformed to crystal form I through melting method. Conclusion: Organic solvents have significant influences on the two crystal forms of title compound. Crystal form I shows a better thermal stability than crystal form II.

%K SU2162 %K Polymorphism %K Crystal Form %K Melting Method %K Solvent Method %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=41735