%0 Journal Article
%T FABP-2 and PPAR-<i>¦Ã</i> Haplotype as Risk Factors for Dyslipidemia in a Type 2 Diabetes Mellitus Population of Santa Rosa del Conlara, San Luis, Argentina
%A Susana Siewert
%A Mar¨ªa Florencia Olmos Nicotra
%A Irma Ines Gonzalez
%A Gustavo Fernandez
%A Marta Susana Ojeda
%J Open Access Library Journal
%V 1
%N 7
%P 1-13
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1100967
%X Introduction:
Type 2 Diabetes Mellitus (T2DM) is a complex disorder caused by the interaction
between genetic predisposition and environmental factors. Genetics plays an important
role on lipid homeostasis. Many genes are involved in the lipid metabolism, such
as FABP-2 and PPAR-<i>¦Ã</i>. Aim: To evaluate
the association between specific SNPs and haplotypes of the FABP-2 and PPAR-<i>¦Ã</i> genes with T2DM and lipid profile in an
Argentinean population. Methods: The FABP-2 (rs1799883)
and PPAR-<i>¦Ã</i> (rs1801282) polymorphisms were
genotyped and analyzed in association with lipid profile and T2DM, separately and
also combined in haplotypes. Results: The frequency of the rare Thr54 allele of
the FABP-2 polymorphism in control (0.33) was not different from the frequency in
T2DM (0.27), whereas the frequency of the rare Ala12 allele of the PPAR-<i>¦Ã</i> polymorphism in control was different from
the frequency in T2DM (0.26 and 0.14, respectively; p = 0.0031). Frequencies of
haplotypes for these two single-nucleotide polymorphisms differed significantly
in control and T2DM. Haplotype association analysis showed the associations between
ThrPro haplotype and TG levels (OR = 2.520; 95% CI = 1.139 - 5.575; p = 0.027) and
between ThrPro haplotype and TC and LDL-c levels when compared to AlaPro haplotype
(difference = 0.175, 95% CI = 0068 - 0.499, p < 0.0001; difference = 0.052, 95%
CI = 0.017 - 0.158, p < 0.0001, respectively). Conclusions: These results from
a haplotype analysis show for the first time that genetic combinations of alleles
of the FABP-2 and PPAR-<i>¦Ã</i> gene could play
a role in the susceptibility to develop dyslipemia in T2DM.
%K Type 2 Diabetes Mellitus
%K FABP-2
%K PPAR-¦Ã
%K Polymorphism
%K Haplotypes
%K Dyslipemia
%U http://www.oalib.com/paper/3106472