%0 Journal Article
%T Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer
%A Laura Boldrini
%A Mirella Giordano
%A Adele Servadio
%A Greta Al¨¬
%A Alice Cocco
%A Marco Lucchi
%A Pietro Bertoglio
%A Franca Melfi
%A Alfredo Mussi
%A Gabriella Fontanini
%J Advances in Lung Cancer
%P 45-51
%@ 2169-2726
%D 2014
%I Scientific Research Publishing
%R 10.4236/alc.2014.32007
%X <p class=\"MsoNormal\" style=\"text-align:justify;\">
	<span lang=\"EN-US\" style=\"font-size:5.5pt;font-family:'}', serif;\"><span style=\"font-size:12px;font-family:Verdana;\">Background: Published data have shown
that microRNAs (miRNAs) could play a potential role as diagnostic and
prognostic indicators in cancers. Data for the predictive value of miRNA let-7,
miR-21, and miR-205 are inconclusive. The aim of the present analysis was
therefore to evaluate the expression and the prognostic role of the above
mentioned miRNAs</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\">&nbsp;</span><span style=\"font-size:12px;font-family:Verdana;\">in early-stage</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\">&nbsp;</span><span style=\"font-size:12px;font-family:Verdana;\">(T1N0) NSCLC patients. Methods: Quantification
of let-7g, miR-21, and miR-205 expression was carried out into 105 early-stage
NSCLC by quantitative Real Time-PCR (qRT-PCR).</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\">&nbsp;</span><span style=\"font-size:12px;font-family:Verdana;\">Results: a significant association
between the low miR-205 expression and ADC histotype (p</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\">&nbsp;</span></span><span lang=\"EN-US\" style=\"font-size:12px;font-family:Verdana;\">&lt;</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\"><span lang=\"EN-US\" style=\"font-size:12px;font-family:Verdana;\">&nbsp;</span></span><span lang=\"EN-US\" style=\"font-size:5.5pt;font-family:'}', serif;\"><span style=\"font-size:12px;font-family:Verdana;\">0.0001) compared to SCC</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\">&nbsp;</span><span style=\"font-size:12px;font-family:Verdana;\">was
found; moreover, survival analysis showed thattumors with a high</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\">&nbsp;</span><span style=\"font-size:12px;font-family:Verdana;\">miR-205 expression had a significantly
shorter mean PFS and OS compared to the patients with a low expression of this
miRNA (p = 0.02 and p = 0.03, respectively). No other statistically significant
correlations were observed between the analysed miRNAs and the main
clinico-pathological characteristics of the NSCLC patients. Conclusion: The
results indicated that miR-205 could represent a useful marker in the
prognostic management of
%K Non-Small Cell Lung Cancer
%K miR-21
%K let-7g
%K miR-205
%K Prognosis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=47050