%0 Journal Article
%T Enamel matrix derivative has no effect on the chondrogenic differentiation of mesenchymal stem cells
%A Lisanne C. Groeneveldt
%A Callie Knuth
%A Janneke Witte-Bouma
%A Fergal J. OˇŻBrien
%A Eric Farrell
%J Frontiers in Bioengineering and Biotechnology
%D 2014
%I Frontiers Media
%R 10.3389/fbioe.2014.00029
%X Background: Treatment of large bone defects due to trauma, tumor resection, or congenital abnormalities is challenging. Bone tissue engineering using mesenchymal stem cells (MSCs) represents a promising treatment option. However, the quantity and quality of engineered bone tissue are not sufficient to fill large bone defects. The aim of this study was to determine if the addition of enamel matrix derivative (EMD) improves in vitro chondrogenic priming of MSCs to ultimately improve in vivo MSC mediated endochondral bone formation.
%K enamel matrix derivative
%K chondrogenesis
%K mesenchymal stem cells
%K endochondral ossification
%K periodontal diseases
%K differentiation
%K scaffolds
%U http://www.frontiersin.org/Journal/10.3389/fbioe.2014.00029/abstract