%0 Journal Article %T Sensing risk, fearing uncertainty: systems science approach to change %A Ivo P. Janecka %J Frontiers in Computational Neuroscience %D 2014 %I Frontiers Media %R 10.3389/fncom.2014.00030 %X Background: Medicine devotes its primary focus to understanding change, from cells to network relationships; observations of non-linearity are inescapable. Recent events provide extraordinary examples of major non-linear surprises within the societal system: human genome-from anticipated 100,000+ genes to only 20,000+; junk DNA-initially ignored but now proven to control genetic processes; economic reversals-bursting of bubbles in technology, housing, finance; foreign wars; relentless rise in obesity, neurodegenerative diseases. There are two attributes of systems science that are especially relevant to this research: One¡ªit offers a method for creating a structural context with a guiding path to pragmatic knowledge; and, two¡ªit gives pre-eminence to sensory input capable to register, evaluate, and react to change. %K change %K risk %K uncertainty %K systems science %K chaos %K entropy %K cancer %K neuro-degeneration %U http://www.frontiersin.org/Journal/10.3389/fncom.2014.00030/abstract