%0 Journal Article
%T Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells
%A Marie T. Kim
%A John T. Harty
%J Frontiers in Immunology
%D 2014
%I Frontiers Media
%R 10.3389/fimmu.2014.00295
%X Inflammatory cytokines have long been recognized to produce potent APCs to elicit robust T cell responses for protective immunity. The impact of inflammatory cytokine signaling directly on T cells, however, has only recently been appreciated. Although much remains to be learned, the CD8 T cell field has made considerable strides in understanding the effects of inflammatory cytokines throughout the CD8 T cell response. Key findings first identified IL-12 and type I interferons as ¡°signal 3¡± cytokines, emphasizing their importance in generating optimal CD8 T cell responses. Separate investigations revealed another inflammatory cytokine, IL-15, to play a critical role in memory CD8 T cell maintenance. These early studies highlighted potential regulators of CD8 T cells, but were unable to provide mechanistic insight into how these inflammatory cytokines enhanced CD8 T cell-mediated immunity. Here, we describe the mechanistic advances that have been made in our lab regarding the role of ¡°signal 3¡± cytokines and IL-15 in optimizing effector and memory CD8 T cell number and function. Furthermore, we assess initial progress on the role of cytokines, such as TGF-¦Â, in generation of recently described resident memory CD8 T cell populations.
%K signal 3
%K cytokines
%K effector
%K resident memory
%K memory
%K CD8 T cells
%U http://www.frontiersin.org/Journal/10.3389/fimmu.2014.00295/abstract