%0 Journal Article
%T High-Resolution Melting Curve Analysis, a Rapid and Affordable Method for Mutation Analysis in Childhood Acute Myeloid Leukemia
%A Yin Liu
%A Paul S. Gaynon
%A Shuhong Shen
%A Weili Sun
%J Frontiers in Pediatrics
%D 2014
%I Frontiers Media
%R 10.3389/fped.2014.00096
%X Background: Molecular genetic alterations with prognostic significance have been described in childhood acute myeloid leukemia (AML). The aim of this study was to establish cost-effective techniques to detect mutations of FMS-like tyrosine kinase 3 (FLT3), nucleophosmin 1 (NPM1), and a partial tandem duplication within the mixed-lineage leukemia (MLL-PTD) genes in childhood AML.
%K FLT3
%K NPM1
%K MLL
%K high-resolution melting curve analysis
%K acute myeloid leukemia
%K childhood
%U http://www.frontiersin.org/Journal/10.3389/fped.2014.00096/abstract