%0 Journal Article
%T Potential of caveolae in the therapy of cardiovascular and neurological diseases
%A Gemma Navarro
%A Kjell Fuxe
%A Rafael Franco
%J Frontiers in Physiology
%D 2014
%I Frontiers Media
%R 10.3389/fphys.2014.00370
%X Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.
%K A1/A2A adenosine receptor subtype 1/2A
%K cardiotropic
%K cell therapy
%K D1: dopamine receptor subtype 1
%K Down-Regulation
%K Endothelium
%K Gene Therapy
%K GPCR
%K GRK
%K internalization
%K lipid raft
%K neurotropic
%K membrane micro-domain
%K microRNA
%K stem cell
%K traffic.
%U http://www.frontiersin.org/Journal/10.3389/fphys.2014.00370/abstract