页岩气、特低渗透油气藏等非常规油气资源开发已经引起世界各国的高度重视，这些非常规油气储层中普遍存在微纳米孔隙，微纳米孔隙中流体渗流规律的研究是这类储层有效开发的理论基础。同时，随着微机电技术的发展，也迫切需要揭示微机电系统中微纳米孔隙流体运动规律。本文从微纳尺度流动研究中的若干热点问题入手，在总结微纳渗流的研究现状的基础上，重点介绍了分子动力学模拟方法在微纳米尺度渗流中的应用，最后并对微纳渗流的研究趋势进行了展望。 The exploitation of unconventional oil and gas resources, such as, shale gas and special low permeability reservoirs, has attracted the attention of the countries all over the world, these unconventional oil and gas reservoir is widespread in the micro-nanometer pore, the research of fluid seepage discipline in the micro-nanometer pore is the theoretical foundation of the effective development of these reservoir. Besides, with the development of Micro Electro Mechanical systems technology, it’s necessary to reveal fluid seepage discipline in the micro-nanometer pore. Starting from the hotspot issues in micro-nanometer fluid flowing, this paper describes the present state of research in this field, then introduces the molecular dynamics simulation method with emphasis in the application of the micro-nanometer fluid seepage. Finally, the research tendency of micro-nanometer fluid seepage in the future is forecast.